The predicted probability of having positive non‐sentinel lymph nodes in patients who received neoadjuvant chemotherapy for large operable breast cancer
Identifieur interne : 006D19 ( Main/Exploration ); précédent : 006D18; suivant : 006D20The predicted probability of having positive non‐sentinel lymph nodes in patients who received neoadjuvant chemotherapy for large operable breast cancer
Auteurs : T. Evrensel [États-Unis, Turquie] ; R. Johnson [États-Unis] ; G. Ahrendt [États-Unis] ; M. Bonaventura [États-Unis] ; J. S. Falk [États-Unis] ; D. Keenan [États-Unis] ; A. Soran [États-Unis]Source :
- International Journal of Clinical Practice [ 1368-5031 ] ; 2008-09.
Abstract
The accuracy of the nomogram in women with positive sentinel nodes following neoadjuvant chemotherapy (NCT) is unknown. The aim of this study was to evaluate the accuracy of the nomogram in patients receiving NCT. Between December 1999 and December 2005, we identified 233 patients who had a positive sentinel lymph node biopsy (SLNB) and complete axillary lymph node dissection at Magee‐Womens Hospital of University of Pittsburgh Medical Center. Thirty‐two patients (14%) had presented with clinically N0 breast cancer (BC) for which NCT was administered. The computerised BC nomogram was used to calculate the probability of non‐sentinel node metastases utilising tumour size before NCT and after NCT for the same patient. The discrimination of the nomogram was assessed by calculating the area under (AUC) the receiver operating characteristic curve (ROC). The median patient age was 51.5 (range: 39–66) years in the NCT group of patients. Twelve patients (37%) had positive axillary non‐sentinel lymph nodes (NSLNs). The nomogram was first validated in our institution for 201 patients without NCT and the predicted accuracy of the nomogram by the AUC was 0.73. The area under the ROC was identical regardless of whether pre‐ or posttreatment tumour size was used to determine predicted probability of NSLN metastases (0.66). The predictive accuracy of the nomogram was found to have less power for patients receiving NCT (0.66) than the non‐NCT group of patients.
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DOI: 10.1111/j.1742-1241.2006.01265.x
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Evrensel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgical Oncology, Magee‐Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Medical Oncology, Uludag University School of Medicine, Bursa</wicri:regionArea><wicri:noRegion>Bursa</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, R" sort="Johnson, R" uniqKey="Johnson R" first="R." last="Johnson">R. 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Bonaventura</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgical Oncology, Magee‐Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Falk, J S" sort="Falk, J S" uniqKey="Falk J" first="J. S." last="Falk">J. S. Falk</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgical Oncology, Magee‐Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Keenan, D" sort="Keenan, D" uniqKey="Keenan D" first="D." last="Keenan">D. Keenan</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgical Oncology, Magee‐Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Soran, A" sort="Soran, A" uniqKey="Soran A" first="A." last="Soran">A. Soran</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgical Oncology, Magee‐Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">International Journal of Clinical Practice</title><title level="j" type="alt">INTERNATIONAL JOURNAL OF CLINICAL PRACTICE</title><idno type="ISSN">1368-5031</idno><idno type="eISSN">1742-1241</idno><imprint><biblScope unit="vol">62</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1379">1379</biblScope><biblScope unit="page" to="1382">1382</biblScope><biblScope unit="page-count">4</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-09">2008-09</date></imprint><idno type="ISSN">1368-5031</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1368-5031</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The accuracy of the nomogram in women with positive sentinel nodes following neoadjuvant chemotherapy (NCT) is unknown. The aim of this study was to evaluate the accuracy of the nomogram in patients receiving NCT. Between December 1999 and December 2005, we identified 233 patients who had a positive sentinel lymph node biopsy (SLNB) and complete axillary lymph node dissection at Magee‐Womens Hospital of University of Pittsburgh Medical Center. Thirty‐two patients (14%) had presented with clinically N0 breast cancer (BC) for which NCT was administered. The computerised BC nomogram was used to calculate the probability of non‐sentinel node metastases utilising tumour size before NCT and after NCT for the same patient. The discrimination of the nomogram was assessed by calculating the area under (AUC) the receiver operating characteristic curve (ROC). The median patient age was 51.5 (range: 39–66) years in the NCT group of patients. Twelve patients (37%) had positive axillary non‐sentinel lymph nodes (NSLNs). The nomogram was first validated in our institution for 201 patients without NCT and the predicted accuracy of the nomogram by the AUC was 0.73. The area under the ROC was identical regardless of whether pre‐ or posttreatment tumour size was used to determine predicted probability of NSLN metastases (0.66). The predictive accuracy of the nomogram was found to have less power for patients receiving NCT (0.66) than the non‐NCT group of patients.</div></front></TEI><affiliations><list><country><li>Turquie</li><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Evrensel, T" sort="Evrensel, T" uniqKey="Evrensel T" first="T." last="Evrensel">T. Evrensel</name></region><name sortKey="Ahrendt, G" sort="Ahrendt, G" uniqKey="Ahrendt G" first="G." last="Ahrendt">G. Ahrendt</name><name sortKey="Bonaventura, M" sort="Bonaventura, M" uniqKey="Bonaventura M" first="M." last="Bonaventura">M. Bonaventura</name><name sortKey="Falk, J S" sort="Falk, J S" uniqKey="Falk J" first="J. S." last="Falk">J. S. Falk</name><name sortKey="Johnson, R" sort="Johnson, R" uniqKey="Johnson R" first="R." last="Johnson">R. Johnson</name><name sortKey="Keenan, D" sort="Keenan, D" uniqKey="Keenan D" first="D." last="Keenan">D. Keenan</name><name sortKey="Soran, A" sort="Soran, A" uniqKey="Soran A" first="A." last="Soran">A. Soran</name></country><country name="Turquie"><noRegion><name sortKey="Evrensel, T" sort="Evrensel, T" uniqKey="Evrensel T" first="T." last="Evrensel">T. Evrensel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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